Dr. Nicoleta Leopa

Arii de interes medical:

• Chirurgie robotica
• Chirurgia oncologica digestiva
• Chirurgie colorectala
• Chirurgia malignitatilor peritoneale
• Chirurgie citoreductiva (CRS)
• HIPEC (chimioterapie intraperitoneala hipertemica)
• PIPAC (chimioterapie intraperitoneala sub forma de aerosol presurizat)
• Educatie chirurgicala si simulare

Cursuri postuniversitare:

• 2026: Workshop "1st Central & Eastern Europe ISSPP - PIPAC", Bucuresti, Romania
• 2026: Abilitare in Domeniul Medicina - "Surgical management of complex digestive patients: determinants of clinical outcomes", Romania
• 2026: Program de perfectionare in Oncologia Peritoneala, Chirurgie Citoreductiva, HIPEC si PIPAC, ZOL - Ziekenhuis Oost-Limburg, Genk, Belgia
• 2026: Fellow EAES - Chirurgie Oncologica Majora, Chirurgie Robotica, Laparoscopie Avansata si HIPEC, AOUP Azienda Ospedaliero-Universitaria Pisana, Pisa, Italia
• 2026: Certificate of Attendance "LAPCO Trainer" - Program international de formare a formatorilor in Chirurgia Laparoscopica si Educatie Chirurgicala, International (Prof. Tom Cecile, Prof Ken Campbell)
• 2025-2026: Training Program "Rising Stars Academy", EAES (European Association of Endoscopic Surgery), International
• 2025: Cercetator Stiintific Grad III, Academia de Stiinte Medicale, Romania
• 2025: Hands-on Course – Transanal Approaches to neoplasia, leaks and IBD, Belgrad, Serbia
• 2025: ESSO Advanced Hands-on Course on the Management of HIPEC after CRS, Berlin, Germania
• 2024: Webinar on the Treatment of Peritoneal Metastasis from Ovarian Cancer, ESSO, Basingstoke, UK
• 2024: Advanced Course on the Treatment of Peritoneal Surface Malignancy, Basingstoke, UK
• 2024: Hands-on Laparoscopy Course: Foregut MIS and fluorescence guided surgery, Ponderas Academic Hospital, Bucuresti, Romania
• 2023: Doctor in Stiinte Medicale - "Impactul Diabetului Zaharat ca factor de risc asupra Cancerului Colorectal la pacientii operati", Romania
• 2023: Curs - Anemia, Sangele si Prognosticul pacientului chirurgical, Iasi, Romania
• 2023: Curs - Sindromul Metabolic la pacientul chirurgical, Bucuresti, Romania
• 2021: Curs - Chirurgia Gastrointestinala Ghidata ICG, Surgical Training Institute, Ponderas Academic Hospital, Bucuresti, Romania
• 2020: Curs - Chirurgia Ghidata ICG, Surgical Training Institute, Ponderas Academic Hospital, Bucuresti, Romania
• 2019: Curs - Tehnici Minim Invazive Adresate Patologiei Colorectale, Surgical Training Institute, Ponderas Academic Hospital, Bucuresti, Romania
• 2019: Curs - Standarde actuale in managementul cancerului de rect inferior, Iasi, Romania
• 2018: Curs - Laparoscopia in urgentele abdominale, Sinaia, Romania
• 2018: Curs - Valoarea laparoscopiei in sindroamele ocluzive, Sinaia, Romania
• 2017: Curs - Chirurgia laparoscopica a colonului: o indicatie bine stabilita, Iasi, Romania
• 2017: Curs - Cancerul rectal - chirurgie deschisa sau chirurgie minim invaziva, Iasi, Romania

Publicatii:

• Clinical Relevance of Biomarkers in Prostate Cancer: The Role of NKX3.1, AMACR, and Ki-67 in Risk Stratification - A Comprehensive Clinicopathological Analysis. Rosu, M. C., Enciu, M., Aschie, M., Ionescu, C. A., Pundiche, M., Dobrin, N., Stefanov, C., Nicolau, A. A., Nicoleta, Leopa, Caraban, B., Deacu, S., Baltatescu, G. I., Bulbuc, I., Popovici, I. A., & Petcu, L. C. (2026). Chirurgia (Bucharest, Romania : 1990), 121(2), 162–171.
• Toward personalized risk stratification in pediatric idiopathic scoliosis: Integrating LBX1 and MTNR1B polymorphisms with metabolic and lifestyle factors. Manac, I., Manac, F. A., Leopa, Nicoleta, Jurja, S., Surdu, T. V., Surdu, M., Oglinda, I. G., Valcu, A. V., Popescu, S., & Enache, F. D. (2026). Egyptian Pediatric Association Gazette, 74, 42.
• Surgical and Functional Implications of Lenke Type 3 Idiopathic Scoliosis in Children and Adolescents: A Comparative Study. Leopa, Nicoleta, Manac, I., Popescu, R. C., Costea, D. O., Pundiche, M., Jurja, S., Manac, F. A., Surdu, T. V., Surdu, M., Oglinda, I. G., Valcu, A. V., Popescu, S., & Enache, F. D. (2026). Chirurgia (Bucharest, Romania : 1990), 121(1), 85–93.
• The compass project: comprehensive overview of European perceptions of non-technical skills in surgery. Saunders, J., Polyzois, K., Hamadziripi, M., Fassari, A., Tomulescu, V., Kontovounisios, C., Birlog, C., Portelli, M., & Leopa, Nicoleta. (2026). Surgical endoscopy, 40(3), 2499–2513.
• Perioperative Risk in Colon Cancer: The Dual Burden of Tumor-Related Anemia and Cardiac Comorbidity. Leopa, Nicoleta, Badea, A., Pundiche, M., Botnarciuc, M., Ispas, V., Paitici, S., Parepa, I. R., Tocia, C., Dumitru, A., Popescu, I., Ispas, S., Busu, D., & Popescu, R. Z. C. (2025). Chirurgia (Bucharest, Romania : 1990), 120(5), 575–582.
• The Impact of Surgical Approach on Postoperative Recovery and Quality of Life in Obstructed Incisional Hernias. Leopa, Nicoleta, Busu, D., Sarbu, V., Popescu, R. C., Pundiche, M., Viorel, I., Bajan, D., Costea, A. C., Sorina, I., Badea, A., & Costea, D. O. (2025). Chirurgia (Bucharest, Romania : 1990), 120(4), 438–445.
• Association of MTHFR C677T and A1298C Polymorphisms with First-Episode Myocardial Ischemia: A Case-Control Study. Badea, I. A., Daba, L. C., Leopa, Nicoleta, Parepa, I. R., Ispas, S., & Botnarciuc, M. (2025). Genes, 16(8), 858.
• Surgical Outcomes in Acute Right-Sided Colonic Ischemia without Vascular Repair: A Single-Center Experience. Popescu, R. C., Busu, D., Leopa, Nicoleta, Costea, D. O., & Pundiche, M. (2025). Chirurgia (Bucharest, Romania : 1990), 120(2), 151–158.
• Toward Personalized Surgery in Advanced Prostate Cancer: Stratification by PTEN, AR-V7, TP53, TMPRSS2-ERG, and ERBB2 Genetic Alterations. Ionescu, C. A., Cozaru, G. C., Aschie, M., Leopa, Nicoleta, Cimpineanu, B., Voinea, F., Matei, E., Mitroi, A., Deacu, M., Iorga, I., & Pundiche, M. (2025). Chirurgia (Bucharest, Romania : 1990), 120(3), 265–274.
• Intestinal permeability assessed by serum zonulin in liver cirrhosis: A systematic review and meta-analysis. Dumitru, A., Tocia, C., Dumitru, E., Stanigut, A. M., Cozaru, G. C., Matei, E., Petcu, L. C., Popescu, R. C., Leopa, Nicoleta, & Rugina, S. (2025). Medicine, 104(16), e42197.
• Predictive Markers for Surgical Indication in Sigmoid Volvulus with Grade II Ischemia, Dumitru Busu, Vasile Sarbu, Mihaela Pundiche, Razvan Catalin Popescu, Daniel Ovidiu Costea, Ispas Viorel, Andrei Dumitru, Cristina Tocia, Ioana Popescu, Ispas Sorina, Nicoleta Leopa (2025), Chirurgia (Bucharest, Romania : 1990)
• The Impact of Minimally Invasive Surgery in Patients with Colorectal Cancer and Type 2 Diabetes Mellitus. Leopa, Nicoleta, Pundiche, M., Dan, C., Nitu, T. S., Paitici, S., Badea, A., Nicoara, A. D., & Popescu, R. C. (2025). Chirurgia (Bucharest, Romania : 1990), 120(1), 71–78.
• A Therapeutic Solution in Vicious Ankylosis After Developmental Dislocation of the Operated Hip - Case Study. Burnei, G., Dragomir, M., Banculescu, M., Popescu, R. C., Leopa, Nicoleta, & Iordache, I. E. (2025). Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 9(3), e24.00284.
• Cutting Edge: A Comprehensive Guide to Colorectal Cancer Surgery in Inflammatory Bowel Diseases. Iordache, I. E., Herlo, L.-F., Popescu, R., Costea, D. O., Alexandrescu, L., Suceveanu, A. P., Deacu, S., Baltatescu, G. I., Nicoara, A. D., Leopa, Nicoleta, Nelson Twakor, A., Iordache, A. O., & Steriu, L. (2025). Journal of Mind and Medical Sciences, 12(1), 6.
• Young RAES Minimally Invasive Surgery Training and Education Survey in Romania. Leopa, Nicoleta, Pirianu, C., Makkai-Popa, S. T., Paitici, S., Enciu, O., Marian, R., Aprodu, S., Faur, F. I., Bocse, H., Puscasu, A., Mandi, D. M., Turcu, F., Popescu, R. C., Copăescu, C., & Birlog, C. (2024). Chirurgia (Bucharest, Romania : 1990), 119(6), 712–720.
• Twisted Troubles: A Rare Case of Intestinal Obstruction Due to Endometriosis and a Review of the Literature. Iordache IE, Alexandrescu L, Nicoara AD, Popescu R, Leopa Nicoleta, Baltatescu G, Nelson Twakor A, Tofolean IT, Steriu L. Clin Pract. 2024 Sep 27;14(5):2027-2043. doi: 10.3390/clinpract14050160.
• The Impact of Age on the Outcomes Following High Ligation and Stripping for Lower Extremity Venous Insufficiency: A Cohort Study. Pundiche M, Leopa Nicoleta, Bajan D, Cindea I, Iosif D, Chisoi A, Popescu RC. Chirurgia (Bucur). 2024 Oct;119(5):565-571. doi: 10.21614/chirurgia.3048.
• Laparoscopic Lateral Hysteropexy versus Hysterosacropexy in Women with Stage III Uterine Prolapse. Nitu, I., Sarbu, V., Savin, S., Sabina, N., Serban, S., Popescu, S., Nitu, T. S., Pundiche, M., Popescu, R. C., & Leopa, Nicoleta. (2025). Chirurgia (Bucharest, Romania : 1990), 120(1), 96–102.
• Prevention of delayed gastric emptying after right colectomy with extended lymphadenectomy: A randomized controlled trial. Popescu, R. C., Leopa, Nicoleta, Iordache, I. E., Dan, C., Moldovan, C., Ghioldis, A. C., Olteanu, C. M., Kacani, A., Cindea, I., & Popescu, I. (2023). Medicine, 102(38), e35255.
• TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population. Mitroi, A. F., Leopa, Nicoleta, Dumitru, E., Dumitru, A., Tocia, C., Popescu, I., Mitroi, A., & Popescu, R. C. (2023). Medicine, 102(7), e33056.
• Tissue and Circulating MicroRNA-31, MicroRNA-200b, and MicroRNA-200c reflects disease activity in Crohn's Disease Patients: Results from the BIOMIR Study. Tocia C, Dumitru A, Mateescu B, Negreanu L, State M, Cozaru GC, Mitroi AF, Brinzan C, Popescu R, Leopa Nicoleta, Iordache MM, Manea M, Matei E, Dumitru E, Alexandrescu L. J Gastrointestin Liver Dis. 2023 Mar 31;32(1):30-38.
• Laparoscopic Approach in the Surgical Management of McKittrick–Wheelock Syndrome. Popescu RC, Ghioldis AC, Dan C, Bosneagu RD, Olteanu CM, Leopa Nicoleta. J Surgery. 2023; 3(2): 1135.
• Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery. Popescu RC, Leopa Nicoleta, Dumitru E, Mitroi AF, Tocia C, Dumitru A, Brinzan C, Botea F. Exp Ther Med. 2022 Aug 2;24(4):611. doi: 10.3892/etm.2022.11548.
• Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus. Mitroi AF, Leopa Nicoleta, Dumitru E, Brinzan C, Tocia C, Dumitru A, Popescu RC. Genes (Basel). 2022 Jul 22;13(8):1297.
• Extended Lymphadenectomy for Proximal Transverse Colon Cancer: Is There a Place for Standardization? Popescu RC, Botea F, Dumitru E, Mazilu L, Micu LG, Tocia C, Dumitru A, Croitoru A, Leopa Nicoleta. Medicina. 2022; 58(5):596.
• The Clinicopathological Differences of Colon Cancer in Young Adults Versus Older Adults. Leopa Nicoleta, Dumitru E, Dumitru A, Tocia C, Prazaru MD, Costea DO, Popescu RC. J Adolesc Young Adult Oncol. 2022 Mar 18. doi: 10.1089/jayao.2021.0184.
• Middle Pulmonary Lobe Abscess: A Delayed Complication of Laparoscopic Cholecystectomy. Leopa Nicoleta, Pavaloiu VC, Pundiche M, Bosneagu R, Popescu RC. Chirurgia (Bucur). 2022;117(3):357-361.
• Colorectal Cancer in Patients With Diabetes Mellitus. Leopa, Nicoleta, Andrei Dumitru, Anca Mitroi, Cristina Tocia, and Razvan Popescu. 2021. Romanian Journal of Diabetes Nutrition and Metabolic Diseases 28 (1), 47-53.
• Ventralex® ST Patch for Laparoscopic Repair of Ventral Hernias. Popescu RC, Botea F, Dan C, Iordache IE, Ghioldis A, Leopa Nicoleta. JSLS. 2021 Oct-Dec;25(4):e2021.00071.
• Molecular profiling of the colon cancer in South-Eastern Romania: Results from the MERCUR study. Popescu RC, Tocia C, Brinzan C, Cozaru GC, Deacu M, Dumitru A, Leopa Nicoleta, Mitroi AF, Nicolau A, Dumitru E. Medicine (Baltimore). 2021 Jan 8;100(1):e24062.
• Global Technical Variations in Roux-en-Y Gastric Bypass: A Worldwide Survey Among IFSO Members. Nicoleta Leopa, collaborative group, Obesity surgery, 10.1007/s11695-026-08724-z.
• Residual Gallbladder and Cystic Duct Stump Stone after Cholecystectomy: Laparoscopic Management. Popescu RC, Leopa Nicoleta, Dumitru A, Dan C, Dosa A, Bosneagu R, Iordache IE, Botea F. Chirurgia (Bucur). 2021 Aug;116(4):484-491.
• D2 Lymphadenectomy as an Independent Prognostic Factor in Gastric Cancer. Cristina D., Catalin P., Ovidiu C., Mihaela P., Cristian G., Dragos B. and Nicoleta Leopa. (2020) ARS Medica Tomitana, Vol.26 (Issue 4), pp. 181-187.
• Colon Cancer in Patients with Crohn’s Disease and Diabetes Mellitus. Catalin, Popescu Razvan, Nicoleta, Leopa, Gentiana, Micu Luminita, Ovidiu, Costea Daniel, Minodora, Olteanu Cornelia, Florin, Ciobanu and Andrei, Dumitru. ARS Medica Tomitana, vol.26, no.3, 2020, pp.150-153.
• Multivisceral Resection of Advanced Sigmoid Colon Cancer. Razvan, Popescu, Leopa Nicoleta, Ionut, Iorga, Nicolau, Antonela-Anca and Andrei, Ghioldis. ARS Medica Tomitana, vol.26, no.2, 2020, pp.95-99.
• Vicios Appendix Position Clinical Case. Ionut-Eduard Iordache, Razvan Popescu, Liliana Steriu, Gabriela Baltatescu, Denisa Mircea, Nicoleta Leopa, Anca Mitroi and Dan Costea. ARS Medica Tomitana, vol.26, no.3, 2020, pp.122-125.
• Mammary Fistula - From Concept to Reality. Ionut-Eduard I., Octavian U., Dan C., Razvan P., Sabina N., Mirela G., Liliana S., Nicoleta Leopa, Gabriela B., & Maria T. (2019). ARS Medica Tomitana, 25(2), 87-94.
• Etiopathogenic Correlations in Breast Cancer. Ionut-Eduard I., Dan C., Mirela G., Sabina N., Liliana S., Nicoleta Leopa, Gabriela B., Maria T., & Razvan P. (2019). ARS Medica Tomitana, 25(3), 100-106.

Membru in societati medicale:

• Asociatia Romana de Chirurgie Endoscopica (ARCE) – Presedintele comitetului Young ARCE
• European Association of Endoscopic Surgery (EAES)
• Peritoneal Surface Oncology Group International (PSOGI)
• International Society for Study of Pleura and Peritoneum (ISSPP)
• Societatea Romana de Chirurgie (SRC)
• Societatea Romana de Coloproctologie (SRCP)
• European Society of Coloproctology (ESCP)